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KMID : 0380020180330030155
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Korean Journal of Biotechnology and Bioengineering
2018 Volume.33 No. 3 p.155 ~ p.160
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Anti-inflammatory Activity of Rumex acetosella Extracts from Jeju Island
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Yang Eun-Jin
Hyun Kwang-Hee
Choi Hae-Ri
Kim Seung-Young
Hyun Chang-Gu
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Abstract
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The anti-inflammatory activity and ignorable toxicity of Rumex acetosella extract (J9) were investigated and confirmed by measuring the expression level of NO, PGE2, and pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) in lipopolysaccharide (LPS)- and J9-treated in RAW264.7 macrophages. Relative to a LPS-only-treated group, the inhibition effect of J9 on the production of NO, PGE2, pro-inflammatory cytokines was increasing across J9-treated samples but the cell viabilities stayed constant. We also exhibited that the iNOS expression level in the J9-treated samples was dose-dependently decreased relative to its untreated control and the elevated expression level of COX-2 seemed to be equal across samples treated with LPS alone or in combination with J9.
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KEYWORD
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Rumex acetosella, anti-inflammatory, lipopolysaccharide, iNOS, COX-2
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